
Retatrutide: the most powerful weight-loss drug yet
Phase 2 trial participants on the highest dose lost about a quarter of their body weight, and Phase 3 went higher still. But one in six stopped taking it. Powerful
Evidence-based guidance on semaglutide, tirzepatide, and the other GLP-1 medications we prescribe at Mindful Wellness — how they work, what to expect, what they cost, and how we decide which one fits. Written and reviewed by Dr. Vivek Gupta, board certified in Internal Medicine and Obesity Medicine.

Phase 2 trial participants on the highest dose lost about a quarter of their body weight, and Phase 3 went higher still. But one in six stopped taking it. Powerful

GLP-1 medications slow the gut on purpose, which is part of how they work and part of why constipation happens. The four categories of laxative, what each one does, and

The first GLP-1 pill for weight management is approved, and orforglipron, CagriSema and retatrutide are behind it. What the trial numbers actually show, side effects included.